Quantinuum is developing new frameworks for artificial intelligence
How do machines “learn”?
While recent years have seen incredible advancements in Artificial Intelligence (AI), no-one really knows how these ‘first-gen’ systems actually work. New work at Quantinuum is helping to develop different frameworks for AI that we can understand - making it interpretable and accountable and therefore far more fit for purpose.
The current fascination with AI systems built around generative Large Language Models (LLMs) is entirely understandable, but lost amid the noise and excitement is the simple fact that AI tech in its current form is basically a “black box” that we can’t look into or examine in any meaningful manner. This is because when computer scientists were starting to figure out how to make machines ‘human like’ and ‘think’, they turned to our best model for a thinking machine, the human brain. The human brain essentially consists of neural networks, and so computer scientists developed artificial neural networks.
However, just as we don’t fully understand how human intelligence works, it’s also true that we don’t really understand how current artificial intelligence works – neural networks are notoriously difficult to interpret and understand. This is broadly described as the “interpretability” issue in AI.
It is self-evident that interpretability is crucial for all kinds of reasons – AI has the power to cause serious harm alongside immense good. It is critical that users understand why a system is making the decisions it does. When we read and hear about ‘safety concerns’ with AI systems, interpretability and accountability are key issues.
At Quantinuum we have been working on this issue for some time – and we began way before AI systems such as generative LLM’s became fashionable. In our AI team based out of Oxford, we have been focused on the development of frameworks for “compositional models” of artificial intelligence. Our intentions and aims are to build artificial intelligence that is interpretable and accountable. We do this in part by using a type of math called “category theory” that has been used in everything from classical computer programming to neuroscience.
Category theory has proven to be a sort of “Rosetta stone”, as John Baez put it, for understanding our universe in an expansive sense – category theory is helpful for things as seemingly disparate as physics and cognition. In a very general sense, categories represent things and ways to go between things, or in other words, a general science of systems and processes. Using this basic framework to understand cognition, we can build new artificial intelligences that are more useful to us – and we can build them on quantum computers, which promise remarkable computing power.
Our AI team, led by Dr. Stephen Clark, Head of AI at Quantinuum, has published a new paper applying these concepts to image recognition. They used their compositional quantum framework for cognition and AI to demonstrate how concepts like shape, color, size, and position can be learned by machines – including quantum computers.
“In the current environment with accountability and transparency being talked about in artificial intelligence, we have a body of research that really matters, and which will fundamentally affect the next generation of AI systems. This will happen sooner than many anticipate” said Ilyas Khan, Quantinuum’s founder.
This paper is part of a larger body of work in quantum computing and artificial intelligence, which holds great promise for our future - as the authors say, “the advantages this may bring, especially with the advent of larger, fault-tolerant quantum computers in the future, is still being worked out by the research community, but the possibilities are intriguing at worst and transformational at best.”
About Quantinuum
Quantinuum, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. Quantinuum’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, Quantinuum leads the quantum computing revolution across continents.
- Mitsui & Co. and Mitsubishi Electric demonstrated one of the world’s largest approximate Quantum Fourier Transforms (QFT) on Quantinuum Helios, scaling from prior records to 98 physical qubits.
- The collaboration also implemented a logical QFT using a QEC (Quantum Error Correction) code with up to 12 logical qubits.
- The work highlights Quantinuum’s accuracy and flexible architecture.
While there is ongoing debate around the pace of quantum computing’s development, a more grounded way to assess progress is through concrete demonstrations of foundational algorithms at meaningful scale. In this context, Mitsui & Co. and Mitsubishi Electric are taking a pragmatic view of quantum progress—focusing on how close the field is to executing core algorithmic primitives that underpin many potential industrial applications, rather than relying on abstract milestones or timelines.
In a new white paper, the industrial giants teamed up with Quantinuum to measure how close we are to running the Quantum Fourier Transform (QFT), a widely-used algorithmic primitive, at scales necessary for industrial applications. In the process, the team successfully ran one of the largest instances of the approximate QFT ever demonstrated. This achievement matters because the QFT is an essential primitive that underpins many of the quantum algorithms expected to deliver practical advantages.
You may have heard of the (classical) Fourier transform (FT), due to its ubiquity throughout modern computing. The FT is essential in everything from image analysis to data compression, with almost limitless applications in between. The quantum Fourier transform (QFT) is similar; it’s used in everything from chemistry to finance.
Because the QFT is a foundational primitive underpinning many quantum algorithms, demonstrating it at larger scales and higher fidelity is a practical way to measure quantum computing readiness. This is exactly the type of benchmarking that organizations should consider to understand where today’s systems are useful, and to see how fault-tolerant approaches are progressing. Ultimately, algorithm-level benchmarking like this is one of the most useful ways to understand not just where we are, but where we are going.
A Transformative Approach
Primitives like Fourier Transform are so widespread because they simplify problems by transforming them into something that is easier to deal with. At Quantinuum, we are very interested in transforms: not only are they crucial for industrial applications but they can also simplify algorithms, making them possible to run now instead of later. This ‘transformational’ approach extends beyond the QFT - other transforms exist, and we have even invented our own quantum-native transforms.
Using our Helios quantum computer and Guppy language, the joint team explored running the QFT on both physical qubits and on logical qubits, showing that fault tolerance is progressing quickly. Running the QFT on 98 physical qubits; the paper shows a clear progression from previous results.
Then, using the Steane code, one of the best-studied quantum error correcting codes, the team used Helios’ 98 physical qubits to form 12 logical qubits, successfully running the QFT with the mechanisms of quantum error correction interwoven into the algorithm. This marks a crucial step forward for the field.
Foundational Progress
Taken together, these results provide a more concrete lens through which to view progress in quantum computing: not as abstract projections, but as measurable advances in the execution of foundational algorithms at increasing scale. By benchmarking the Quantum Fourier Transform on both physical and logical qubits, Mitsui & Co. and Mitsubishi Electric are helping to clarify what today’s hardware can already achieve, and where fault-tolerant approaches begin to extend those limits.
More broadly, the organizations best positioned to benefit from quantum computing will be those that focus on these foundational capabilities early, and use them to build a clear, evidence-based understanding of how the technology fits into their business goals.
It is believed that unlocking answers to some of the most complex scientific and industrial problems will require the seamless integration of high-performance computing (HPC), generative AI (GenAI), and quantum computing. Toward this goal, Quantinuum, NVIDIA, and a major pharmaceutical company have successfully demonstrated the first step in a proof-of-principle framework designed to connect these three distinct computing paradigms for industrially relevant computational chemistry.
This milestone, enabled by three industry leaders and experts in their respective domains, serves as a foundational capability that could support the development of future hybrid quantum-AI workflows to help optimize industrial research and development (R&D).
The potential value is a path toward more automated, repeatable, and scalable workflows for translating chemistry problems into executable quantum programs—capabilities that could eventually make hybrid computing easier to deploy in industrial R&D.
The GenQAI Framework
The framework, termed Generative Quantum AI (GenQAI), involved a quantum computer simulating a pharmaceutical compound using programming instructions generated by an AI model, which itself was trained on quantum data that was simulated using HPC.
While the vision for GenQAI explores how future industrial simulation workflows might be optimized by training AI models using quantum data derived directly from a quantum computer, the framework currently consists of four main technical steps:
- Simulating quantum data: The process began by simulating quantum data with NVIDIA accelerated computing using NVIDIA CUDA-Q.
- Fine-tuning the AI: This simulated quantum data was used to fine-tune a pre-trained AI model from the open NVIDIA Nemotron family.
- Generating instructions: The AI model then generated quantum circuits, which are the programming instructions required for the quantum simulation.
- Validating accuracy: To validate the results, the circuits were run on Quantinuum’s Helios quantum computer using its InQuanto quantum chemistry platform.
The core novelty of this development lies within the process of the framework itself. In this proof-of-principle experiment, an AI model fine-tuned on simulated quantum data generated circuits that were successfully executed and validated on Quantinuum’s Helios system. Rather than delivering an immediate commercial advantage, this achievement establishes a credible, verifiable baseline for how HPC, AI, and quantum computing can function in tandem.
The Case Study
The validation of the framework represents an early step toward the goal of developing scalable architectures for the pharmaceutical industry.
With a shared view toward eventually scaling the framework for pharmaceutical R&D applications, the researchers simulated a pharmaceutical compound: imipramine. This anti-depressant was chosen because it serves as a model compound for drug degradation and shelf-life studies, which are standard components of the pharmaceutical R&D lifecycle.
Developing hybrid infrastructure that enterprises may adopt requires a deep, coordinated effort among domain experts. As such, this successful test highlights the value of combining the strengths of a quantum computing hardware and software leader (Quantinuum), with a hybrid-quantum classical platform (NVIDIA), and a leading enterprise end-user to build and test future computing capabilities for industrial chemistry.
Scaling the Framework
Although demonstrated on a pharmaceutical compound, the architecture could eventually inform similar molecular-simulation workflows in sectors such as energy, agriculture, advanced materials, and electronics. At this stage, it provides a reference for further testing and development.
Engage Further
Access the paper here to explore the full technical details of this demonstration and contact our team to learn more about joining Quantinuum’s enterprise partner network.
Quantinuum is pleased to announce that applications are now open for the Quantinuum SG Grand Challenge 2026, a global innovation challenge designed to bring together researchers, developers, scientists and innovators to explore practical applications of quantum computing.
Organized by Quantinuum and supported by Singapore's National Quantum Office and Aqora, the three-month program aims to foster collaboration across academia, industry and the quantum developer community while supporting the continued growth of Singapore's quantum ecosystem.
A Platform for Quantum Computing Innovation
Participants will work in teams to develop solutions across a range of challenge areas, including chemistry and molecular simulation, optimization, AI for quantum systems, quantum error correction, condensed matter and materials science, and open innovation. Throughout the program, participants will have access to mentoring, technical enablement and Quantinuum quantum computing resources.
Singapore Grand Finale
Selected finalist teams will be invited to present their work at the Grand Finale hosted in Singapore before representatives from academia, and industry. The event will celebrate innovative applications of quantum computing while providing an opportunity for participants to engage with Singapore's growing quantum community.
Join the Challenge
The Quantinuum SG Grand Challenge welcomes participants from around the world. Whether you are an experienced quantum researcher or beginning your quantum computing journey, the program offers an opportunity to collaborate, learn and contribute to the development of practical quantum applications.
Applications are now open. Spaces are limited and subject to review and approval.