InQuanto Integrates NVIDIA cuQuantum for Native GPU Support and Prepares for the Era of Quantum Supercomputing
With quantum progress accelerating, we introduce InQuanto v4.0 and explain how it supports customers and researchers exploring the application of AI, HPC and quantum computing – A.K.A. Quantum Supercomputing – to problems in chemistry and related fields
Chemistry plays a central role in the modern global economy, as it has for centuries. From Antoine Lavoisier to Alessandro Volta, Marie Curie to Venkatraman Ramakrishnan, pioneering chemists drove progress in fields such as combustion, electrochemistry, and biochemistry. They contributed to our mastery of critical 21st century materials such as biodegradable plastics, semiconductors, and life-saving pharmaceuticals.
Advances in high-performance computing (HPC) and AI have brought fundamental and industrial science ever more within the scope of methods like data science and predictive analysis. In modern chemistry, it has become routine for research to be aided by computational models run in silico. Yet, due to their intrinsically quantum mechanical nature, “strongly correlated” chemical systems – those involving strongly interacting electrons or highly interdependent molecular behaviors – prove extremely hard to accurately simulate using classical computers alone. Quantum computers running quantum algorithms are designed to meet this need. Strongly correlated systems turn up in potential applications such as smart materials, high-temperature superconductors, next-generation electronic devices, batteries and fuel cells, revealing the economic potential of extending our understanding of these systems, and the motivation to apply quantum computing to computational chemistry.
For senior business and research leaders driving value creation and scientific discovery, a critical question is how will the introduction of quantum computers affect the trajectory of computational approaches to fundamental and industrial science?
Introducing InQuanto v4.0
This is the exciting context for our announcement of InQuanto v4.0, the latest iteration of our computational chemistry platform for quantum computers. Developed over many years in close partnership with computational chemists and materials scientists, InQuanto has become an essential tool for teams using the most advanced methods for simulating molecular and material systems. InQuanto v4.0 is packed with powerful updates, including the capability to incorporate NVIDIA’s tensor network methods for large-scale classical simulations supported by graphical processing units (GPUs).
When researching chemistry on quantum computers, we use classical HPC to perform tasks such as benchmarking, and for classical pre- and post-processing with computational chemistry methods such as density functional theory. This powerful hybrid quantum-classical combination with InQuanto accelerated our work with partners such as BMW Group, Airbus, and Honeywell. Global businesses and national governments alike are gearing up for the use of such hybrid “quantum supercomputers” to become standard practice.
In a recent technical blog post, we explored the rapid development and deployment of InQuanto for research and enterprise users, offering insights for combining quantum and high-performance classical methods with only a few lines of code. Here, we provide a higher-level overview of the value InQuanto brings to fundamental and industrial research teams.
InQuanto v4.0 – under the hood
InQuanto v4.0 is the most powerful version to date of our advanced quantum computational chemistry platform. It supports our users in applying quantum and classical computing methods to problems in chemistry and, increasingly, adjacent fields such as condensed matter physics.
Like previous versions of InQuanto, this one offers state-of-the-art algorithms, methods, and error handling techniques out of the box. Quantum error correction and detection have enabled rapid progress in quantum computing, such as groundbreaking demonstrations in partnership with Microsoft, in April and September 2024, of highly reliable “logical qubits”. Qubits are the core information-carrying components of a quantum computer and by forming them into an ensemble, they are more resistant to errors, allowing more complex problems to be tackled while producing accurate results. InQuanto continues to offer leading-edge quantum error detection protocols as standard and supports users to explore the potential of algorithms for fault-tolerant machines.
InQuanto v4.0 also marks the significant step of introducing native support for tensor networks using GPUs to accelerate simulations. In 2022, Quantinuum and NVIDIA teamed up on one of the quantum computing industry’s earliest quantum-classical collaborations. InQuanto v4.0 introduces classical tensor network methods via an interface with NVIDIA's cuQuantum SDK. Interfacing with cuQuantum enables the simulation of many quantum circuits via the use of GPUs for applications in chemistry that were previously inaccessible, particularly those with larger numbers of qubits.
“Hybrid quantum-classical supercomputing is accelerating quantum computational chemistry research. With Quantinuum’s InQuanto v4.0 platform and NVIDIA’s cuQuantum SDK, InQuanto users now have access to unique tensor-network-based methods, enabling large-scale and high-precision quantum chemistry simulations” - Tim Costa, Senior Director of HPC and Quantum Computing at NVIDIA
We are also responding to our users’ needs for more robust, enterprise-grade management of applications and data, by incorporating InQuanto into Quantinuum Nexus. This integration makes it far easier and more efficient to build hybrid workflows, decode and store data, and use powerful analytical methods to accelerate scientific and technical progress in critical fields in natural science.
Adding further capabilities, we recently announced our integration of InQuanto with Microsoft’s Azure Quantum Elements (AQE), allowing users to seamlessly combine AQE’s state-of-the-art HPC and AI methods with the enhanced quantum capabilities of InQuanto in a single workflow. The first end-to-end workflow using HPC, AI and quantum computing was demonstrated by Microsoft using AQE and Quantinuum Systems hardware, achieving chemical accuracy and demonstrating the advantage of logical qubits compared to physical qubits in modeling a catalytic reaction.
Where InQuanto takes us next
In the coming years, we expect to see scientific and economic progress using the powerful combination of quantum computing, HPC, and artificial intelligence. Each of these computing paradigms contributes to our ability to solve important problems. Together, their combined impact is far greater than the sum of their parts, and we recognize that these have the potential to drive valuable computational innovation in industrial use-cases that really matter, such as in energy generation, transmission and storage, and in chemical processes essential to agriculture, transport, and medicine.
Building on our recent hardware roadmap announcement, which supports scientific quantum advantage and a commercial tipping point in 2029, we are demonstrating the value of owning and building out the full quantum computing stack with a unified goal of accelerating quantum computing, integrating with HPC and AI resources where it shows promise, and using the power of the “quantum supercomputer” to make a positive difference in fundamental and industrial chemistry and related domains.
In close collaboration with our customers, we are driving towards systems capable of supporting quantum advantage and unlocking tangible and significant business value.
To access InQuanto today, including Quantinuum Systems and third-party hardware and emulators, visit: https://www.quantinuum.com/products-solutions/inquanto
To get started with Quantinuum Nexus, which meets all your quantum computing needs across Quantinuum Systems and third-party backends, visit: https://www.quantinuum.com/products-solutions/nexus
To find out more and access Quantinuum Systems, visit: https://www.quantinuum.com/products-solutions/quantinuum-systems
About Quantinuum
Quantinuum, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. Quantinuum’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, Quantinuum leads the quantum computing revolution across continents.
One of the greatest privileges of working directly with the world’s most powerful quantum computer at Quantinuum is building meaningful experiments that convert theory into practice. The privilege becomes even more compelling when considering that our current quantum processor – our H2 system – will soon be enhanced by Helios, a quantum computer a stunning trillion times more powerful, and due for launch in just a few months. The moment has now arrived when we can build a timeline for applications that quantum computing professionals have anticipated for decades and which are experimentally supported.
Background
In the 1980s, in the years after Richard Feynman and David Deutsch were working on their initial thoughts around quantum computing, Nicholas Cozzarelli at the University of California, Berkeley, was grappling with a biochemical riddle – “how do enzymes called topoisomerases and recombinases untangle the DNA strands that knot themselves inside cells?”
Cozarelli teamed up with mathematicians including De Witt Sumners, who recognized that these twisted strands could be modelled using the language of knots.
Knot theory’s equations let them deduce how enzymes snipped, flipped and reattached DNA, demystifying processes essential to life. Decoding the knots in DNA proved crucial to designing better antibiotics and in advancing genetic engineering.
Cozzarelli’s team took advantage of the power of knot invariants—polynomial expressions that remain consistent markers of a knot’s identity, no matter how tangled the loops become. This is just one example of how knot theory has been used to solve real-world problems of practical value.
Today, knot theory finds practical uses in fields as diverse as chemistry, robotics, fluid dynamics, and drug design. Measuring the invariants that characterize each knot is a challenge that scales exponentially with the complexity of the knots.
This work shows how a quantum computer can cut through this exponential explosion, indicating that Quantinuum's next-generation systems will offer practical quantum advantage in solving knot theory problems.
In this article, Konstantinos Meichanetzidis, a team leader from Quantinuum’s AI group, explains intriguing and valuable new research into applying quantum computers to addressing problems in knot theory.
Quantifying quantum advantage for knot theory
Quantinuum’s applied quantum algorithms team has published a historic end-to-end algorithm for solving a famous problem in knot theory, via a preprint paper on the arXiv. The research team, led by Konstantinos Meichanetzidis, also included Quantinuum researchers Enrico Rinaldi, Chris Self, Eli Chertkov, Matthew DeCross, David Hayes, Brian Neyenhuis, Marcello Benedetti, and Tuomas Laakkonen of the Massachusetts Institute of Technology.
The project was motivated by building configurable and comprehensive algorithmic tools to pinpoint quantum advantage in practice. This was done by rigorously defining time and error budgets and quantifying both the classical and quantum resource requirements necessary to meet them. Considering realistic quantum and classical processors, they predict that Quantinuum’s forthcoming quantum computers meet those requirements.
Knot theory is a field of mathematics called ‘low-dimensional topology’, with a rich history, stemming from a wild idea proposed by lord Kelvin, who conjectured that chemical elements are different knots formed by vortices in the ether. Of course, we know today that the ether theory did not hold up under experimental scrutiny, but mathematicians have been classifying and studying knots ever since. Knot theory is intrinsically linked with many aspects of physics. For example, it naturally shows up in certain spin models in statistical mechanics. Today, physical properties of knots are important in understanding the stability of macromolecular structures, from DNA and proteins, to polymers relevant to materials design. Knots find their way into cryptography. Even the magnetohydrodynamical properties of knotted magnetic fields on the surface of the sun are an important indicator of solar activity.
Most importantly for our context, knot theory has fundamental connections to quantum computation, originally outlined by Witten’s work in topological quantum field theory, concerning spacetimes without any notion of distance but only shape. In fact, this connection formed the very motivation for attempting to build topological quantum computers, where anyons – exotic quasiparticles that live in two-dimensional materials – are braided to perform quantum gates.
Konstantinos Meichanetzidis, who led the project, said: “The relation between knot theory and quantum physics is the most beautiful and bizarre fact you have never heard of.”
The fundamental problem in knot theory is distinguishing knots, or more generally, links. To this end, mathematicians have defined link invariants, which serve as ‘fingerprints’ of a link. As there are many equivalent representations of the same link, an invariant, by definition, is the same for all of them. If the invariant is different for two links then they are not equivalent. The specific invariant our team focused on is the Jones polynomial.
The mind-blowing fact here is that any quantum computation corresponds to evaluating the Jones polynomial of some link, as shown by the works of Freedman, Larsen, Kitaev, Wang, Shor, Arad, and Aharonov. It reveals that this abstract mathematical problem is truly quantum native. In particular, the problem our team tackled was estimating the Jones polynomial at the 5th root of unity. This is a well-studied case due to its relation to the infamous Fibonacci anyons, whose braiding is capable of universal quantum computation.
Building and improving on the work of Shor, Aharonov, Landau, Jones, and Kauffman, our team developed an efficient quantum algorithm that works end-to end. That is, given a link, it outputs a highly optimized quantum circuit that is readily executable on our processors and estimates the desired quantity. Furthermore, our team designed problem-tailored error detection and error mitigation strategies to achieve a higher accuracy.
In addition to providing a full pipeline for solving this problem, a major aspect of this work was to use the fact that the Jones polynomial is an invariant to introduce a benchmark for noisy quantum computers. Most importantly, this benchmark is efficiently verifiable, a rare property since for most applications, exponentially costly classical computations are necessary for verification. Given a link whose Jones polynomial is known, the benchmark constructs a large set of topologically equivalent links of varying sizes. In turn, these result in a set of circuits of varying numbers of qubits and gates, all of which should return the same answer. Thus, one can characterize the effect of noise present in a given quantum computer by quantifying the deviation of its output from the known result.
The benchmark introduced in this work allows one to identify the link sizes for which there is exponential quantum advantage in terms of time to solution against the state-of-the-art classical methods. These resource estimates indicate our next processor, Helios, with 96 qubits and at least 99.95% two-qubit gate-fidelity, is extremely close to meeting these requirements. Furthermore, Quantinuum’s hardware roadmap includes even more powerful machines that will come online by the end of the decade. Notably, an advantage in energy consumption emerges for even smaller link sizes. Meanwhile, our teams aim to continue reducing errors through improvements in both hardware and software, thereby moving deeper into quantum advantage territory.
The importance of this work, indeed the uniqueness of this work in the quantum computing sector, is its practical end-to-end approach. The advantage-hunting strategies introduced are transferable to other “quantum-easy classically hard” problems.
Our team’s efforts motivate shifting the focus toward specific problem instances rather than broad problem classes, promoting an engineering-oriented approach to identifying quantum advantage. This involves carefully considering how quantum advantage should be defined and quantified, thereby setting a high standard for quantum advantage in scientific and mathematical domains. And thus making sure we instill confidence in our customers and partners.
Quantinuum and NVIDIA, world leaders in their respective sectors, are combining forces to fast-track commercially scalable quantum supercomputers, further bolstering the announcement Quantinuum made earlier this year about the exciting new potential in Generative Quantum AI.
Make no mistake about it, the global quantum race is on. With over $2 billion raised by companies in 2024 alone, and over 150 new startups in the past five years, quantum computing is no longer restricted to ‘the lab’.
The United Nations proclaimed 2025 as the International Year of Quantum Science and Technology (IYQ), and as we march toward the end of the first quarter, the old maxim that quantum computing is still a decade (or two, or three) away is no longer relevant in today’s world. Governments, commercial enterprises and scientific organizations all stand to benefit from quantum computers, led by those built by Quantinuum.
That is because, amid the flurry of headlines and social media chatter filled with aspirational statements of future ambitions shared by those in the heat of this race, we at Quantinuum continue to lead by example. We demonstrate what that future looks like today, rather than relying solely on slide deck presentations.
Our quantum computers are the most powerful systems in the world. Our H2 system, the only quantum computer that cannot be classically simulated, is years ahead of any other system being developed today. In the coming months, we’ll introduce our customers to Helios, a trillion times more powerful than H2, further extending our lead beyond where the competition is still only planning to be.
At Quantinuum, we have been convinced for years that the impact of quantum computers on the real world will happen earlier than anticipated. However, we have known that impact will be when powerful quantum computers and powerful classical systems work together.
This sort of hybrid ‘supercomputer’ has been referenced a few times in the past few months, and there is, rightly, a sense of excitement about what such an accelerated quantum supercomputer could achieve.
The Power of Hybrid Quantum and Classical Compute
In a revolutionary move on March 18th, 2025, at the GTC AI conference, NVIDIA announced the opening of a world-class accelerated quantum research center with Quantinuum selected as a key founding collaborator to work on projects with NVIDIA at the center.
With details shared in an accompanying press statement and blog post, the NVIDIA Accelerated Quantum Research Center (NVAQC) being built in Boston, Massachusetts, will integrate quantum computers with AI supercomputers to ultimately explore how to build accelerated quantum supercomputers capable of solving some of the world’s most challenging problems. The center will begin operations later this year.
As shared in Quantinuum’s accompanying statement, the center will draw on the NVIDIA CUDA-Q platform, alongside a NVIDIA GB200 NVL72 system containing 576 NVIDIA Blackwell GPUs dedicated to quantum research.
The Role of CUDA-Q in Quantum-Classical Integration
Integrating quantum and classical hardware relies on a platform that can allow researchers and developers to quickly shift context between these two disparate computing paradigms within a single application. NVIDIA CUDA-Q platform will be the entry-point for researchers to exploit the NVAQC quantum-classical integration.
In 2022, Quantinuum became the first company to bring CUDA-Q to its quantum systems, establishing a pioneering collaboration that continues to today. Users of CUDA-Q are currently offered access to Quantinuum’s System H1 QPU and emulator for 90 days.
Quantinuum’s future systems will continue to support the CUDA-Q platform. Furthermore, Quantinuum and NVIDIA are committed to evolving and improving tools for quantum classical integration to take advantage of the latest hardware features, for example, on our upcoming Helios generation.
The Gen-Q-AI Moment
A few weeks ago, we disclosed high level details about an AI system that we refer to as Generative Quantum AI, or GenQAI. We highlighted a timeline between now and the end of this year when the first commercial systems that can accelerate both existing AI and quantum computers.
At a high level, an AI system such as GenQAI will be enhanced by access to information that has not previously been accessible. Information that is generated from a quantum computer that cannot be simulated. This information and its effect can be likened to a powerful microscope that brings accuracy and detail to already powerful LLM’s, bridging the gap from today’s impressive accomplishments towards truly impactful outcomes in areas such as biology and healthcare, material discovery and optimization.
Through the integration of the most powerful in quantum and classical systems, and by enabling tighter integration of AI with quantum computing, the NVAQC will be an enabler for the realization of the accelerated quantum supercomputer needed for GenQAI products and their rapid deployment and exploitation.
Innovating our Roadmap
The NVAQC will foster the tools and innovations needed for fully fault-tolerant quantum computing and will be enabler to the roadmap Quantinuum released last year.
With each new generation of our quantum computing hardware and accompanying stack, we continue to scale compute capabilities through more powerful hardware and advanced features, accelerating the timeline for practical applications. To achieve these advances, we integrate the best CPU and GPU technologies alongside our quantum innovations. Our long-standing collaboration with NVIDIA drives these advancements forward and will be further enriched by the NVAQC.
Here are a couple of examples:
In quantum error correction, error syndromes detected by measuring "ancilla" qubits are sent to a "decoder." The decoder analyzes this information to determine if any corrections are needed. These complex algorithms must be processed quickly and with low latency, requiring advanced CPU and GPU power to calculate and apply corrections keeping logical qubits error-free. Quantinuum has been collaborating with NVIDIA on the development of customized GPU-based decoders which can be coupled with our upcoming Helios system.
In our application space, we recently announced the integration of InQuanto v4.0, the latest version of Quantinuum’s cutting edge computational chemistry platform, with NVIDIA cuQuantum SDK to enable previously inaccessible tensor-network-based methods for large-scale and high-precision quantum chemistry simulations.
Our work with NVIDIA underscores the partnership between quantum computers and classical processors to maximize the speed toward scaled quantum computers. These systems offer error-corrected qubits for operations that accelerate scientific discovery across a wide range of fields, including drug discovery and delivery, financial market applications, and essential condensed matter physics, such as high-temperature superconductivity.
We look forward to sharing details with our partners and bringing meaningful scientific discovery to generate economic growth and sustainable development for all of humankind.
In the rapidly advancing world of quantum computing, to be a leader means not just keeping pace with innovation but driving it forward. It means setting new standards that shape the future of quantum computing performance. A recent independent study comparing 19 quantum processing units (QPUs) on the market today has validated what we’ve long known to be true: Quantinuum’s systems are the undisputed leaders in performance.
The Benchmarking Study
A comprehensive study conducted by a joint team from the Jülich Supercomputing Centre, AIDAS, RWTH Aachen University, and Purdue University compared QPUs from leading companies like IBM, Rigetti, and IonQ, evaluating how well each executed the Quantum Approximate Optimization Algorithm (QAOA), a widely used algorithm that provides a system level measure of performance. After thorough examination, the study concluded that:
“...the performance of quantinuum H1-1 and H2-1 is superior to that of the other QPUs.”
Quantinuum emerged as the clear leader, particularly in full connectivity, the most critical category for solving real-world optimization problems. Full connectivity is a huge comparative advantage, offering more computational power and more flexibility in both error correction and algorithmic design. Our dominance in full connectivity—unattainable for platforms with natively limited connectivity—underscores why we are the partner of choice in quantum computing.
Leading Across the Board
We take benchmarking seriously at Quantinuum. We lead in nearly every industry benchmark, from best-in-class gate fidelities to a 4000x lead in quantum volume, delivering top performance to our customers.
Our Quantum Charged-coupled Device (QCCD) architecture has been the foundation of our success, delivering consistent performance gains year-over-year. Unlike other architectures, QCCD offers all-to-all connectivity, world-record fidelities, and advanced features like real-time decoding. Altogether, it’s clear we have superior performance metrics across the board.
While many claim to be the best, we have the data to prove it. This table breaks down industry benchmarks, using the leading commercial spec for each quantum computing architecture.
These metrics are the key to our success. They demonstrate why Quantinuum is the only company delivering meaningful results to customers at a scale beyond classical simulation limits.
Our progress builds upon a series of Quantinuum’s technology breakthroughs, including the creation of the most reliable and highest-quality logical qubits, as well as solving the key scalability challenge associated with ion-trap quantum computers — culminating in a commercial system with greater than 99.9% two-qubit gate fidelity.
From our groundbreaking progress with System Model H2 to advances in quantum teleportation and solving the wiring problem, we’re taking major steps to tackle the challenges our whole industry faces, like execution speed and circuit depth. Advancements in parallel gate execution, faster ion transport, and high-rate quantum error correction (QEC) are just a few ways we’re maintaining our lead far ahead of the competition.
This commitment to excellence ensures that we not only meet but exceed expectations, setting the bar for reliability, innovation, and transformative quantum solutions.
Onward and Upward
To bring it back to the opening message: to be a leader means not just keeping pace with innovation but driving it forward. It means setting new standards that shape the future of quantum computing performance.
We are just months away from launching Quantinuum’s next generation system, Helios, which will be one trillion times more powerful than H2. By 2027, Quantinuum will launch the industry’s first 100-logical-qubit system, featuring best-in-class error rates, and we are on track to deliver fault-tolerant computation on hundreds of logical qubits by the end of the decade.
The evidence speaks for itself: Quantinuum is setting the standard in quantum computing. Our unrivaled specs, proven performance, and commitment to innovation make us the partner of choice for those serious about unlocking value with quantum computing. Quantinuum is committed to doing the hard work required to continue setting the standard and delivering on our promises. This is Quantinuum. This is leadership.
Dr. Chris Langer is a Fellow, a key inventor and architect for the Quantinuum hardware, and serves as an advisor to the CEO.
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